Istanbul (IST) to Madrid (MAD) flights from USD220

*Modifying this information may result in a different fare

*All amounts are in USD. Taxes and surcharges are included. No booking fee is applicable. Fares displayed have been collected within the last 48hrs and may no longer be available at time of booking. 

Why book directly on the KLM website?

Explore the benefits of booking through our website.

No hidden costs icon

No hidden costs

Book with confidence. Our rates hide no unpleasant surprises.

24/7 customer service icon

24/7 customer service

Count on direct, personal support whenever you need it, day or night.

Seamless travel icon

Seamless travel

Enjoy a smooth journey with timely updates and automatic rebooking.

Lowest fares between Istanbul and Madrid

cmp-daily-histogram-bars-legend-min-price-aria-label USD228
cmp-daily-histogram-bars-legend-max-price-aria-label USD1.1K
Displaying fares for September-2026
  • IST–MAD, 06/09/2026 – 09/09/2026: From USD1,107
    06

    Su

    SEP

  • IST–MAD, 07/09/2026 – 10/09/2026: From USD554
    07

    Mo

  • IST–MAD, 08/09/2026 – 29/09/2026: From USD462
    08

    Tu

  • IST–MAD, 09/09/2026 – 12/09/2026: From USD450
    09

    We

  • IST–MAD, 10/09/2026 – 01/10/2026: From USD745
    10

    Th

  • IST–MAD, 11/09/2026 – 18/09/2026: From USD438
    11

    Fr

  • IST–MAD, 12/09/2026 – 19/09/2026: From USD375
    12

    Sa

  • IST–MAD, 13/09/2026 – 16/09/2026: From USD585
    13

    Su

  • IST–MAD, 14/09/2026 – 17/09/2026: From USD269
    14

    Mo

  • IST–MAD, 15/09/2026 – 22/09/2026: From USD273
    15

    Tu

  • IST–MAD, 16/09/2026 – 23/09/2026: From USD263
    16

    We

  • IST–MAD, 17/09/2026 – 01/10/2026: From USD433
    17

    Th

  • IST–MAD, 18/09/2026 – 21/09/2026: From USD437
    18

    Fr

  • IST–MAD, 19/09/2026 – 10/10/2026: From USD244
    19

    Sa

  • IST–MAD, 20/09/2026 – 23/09/2026: From USD354
    20

    Su

  • IST–MAD, 21/09/2026 – 28/09/2026: From USD272
    21

    Mo

  • IST–MAD, 22/09/2026 – 29/09/2026: From USD228
    22

    Tu

  • IST–MAD, 23/09/2026 – 30/09/2026: From USD228
    23

    We

  • IST–MAD, 24/09/2026 – 01/10/2026: From USD338
    24

    Th

  • IST–MAD, 25/09/2026 – 28/09/2026: From USD357
    25

    Fr

  • IST–MAD, 26/09/2026 – 10/10/2026: From USD296
    26

    Sa

  • IST–MAD, 27/09/2026 – 30/09/2026: From USD411
    27

    Su

  • IST–MAD, 28/09/2026 – 01/10/2026: From USD344
    28

    Mo

  • IST–MAD, 29/09/2026 – 06/10/2026: From USD255
    29

    Tu

  • IST–MAD, 30/09/2026 – 03/10/2026: From USD238
    30

    We

  • IST–MAD, 01/10/2026 – 29/10/2026: From USD481
    01

    Th

    OCT

  • IST–MAD, 02/10/2026 – 05/10/2026: From USD410
    02

    Fr

  • IST–MAD, 03/10/2026 – 10/10/2026: From USD249
    03

    Sa

  • IST–MAD, 04/10/2026 – 07/10/2026: From USD393
    04

    Su

  • IST–MAD, 05/10/2026 – 02/11/2026: From USD675
    05

    Mo

  • RangeUSD228-USD1,107